Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI.

ABSTRACT: Diffusion magnetic resonance imaging can reveal quantitative information about the tissue changes in multiple sclerosis. The recently developed multi-compartment spherical mean technique can map different microscopic properties based only on local diffusion signals, and it may provide specific information on the underlying microstructural modifications that arise in multiple sclerosis. Given that the lesions in multiple sclerosis may reflect different degrees of damage, we hypothesized that quantitative diffusion maps may help characterize the severity of lesions "in vivo" and correlate these to an individual's clinical profile. We evaluated this in a cohort of 59 multiple sclerosis patients (62% female, mean age 44.7 years), for whom demographic and disease information was obtained, and w

SUBMITTER: Martinez-Heras E 

PROVIDER: S-EPMC7502564 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature