Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France.

ABSTRACT:

Background

The serologic response of individuals with mild forms of SARS-CoV-2 infection is poorly characterized.

Methods

Hospital staff who had recovered from mild forms of PCR-confirmed SARS-CoV-2 infection were tested for anti-SARS-CoV-2 antibodies using two assays: a rapid immunodiagnostic test (99.4% specificity) and the S-Flow assay (~99% specificity). The neutralizing activity of the sera was tested with a pseudovirus-based assay.

Findings

Of 162 hospital staff who participated in the investigation, 160 reported SARS-CoV-2 infection that had not required hospital admission and were included in these analyses. The median time from symptom onset to blood sample collection was 24 days (IQR: 21-28, range 13-39). The rapid immunodiagnostic test detected antibodies i

SUBMITTER: Fafi-Kremer S 

PROVIDER: S-EPMC7502660 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature