Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia.

ABSTRACT:

Background

Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other genes regulating maternal immune responses.

Methods

We assessed sex ratios and regulatory HLA-G haplotypes in population cohorts and series of preeclampsia and stillbirth. We studied placental mRNA expression of 136 genes by sequencing and HLA-G and interferon alpha (IFNα) protein expression by immunohistochemistry.

Findings

We found underrepresentation of males in preeclamptic births, especially those delivered preterm or small for gestational age. Balancing selection at HLA-G associated with the sex ratio, stillbirth, and preeclampsia. We observed d

SUBMITTER: Wedenoja S 

PROVIDER: S-EPMC7502669 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature