Global transcriptome study of Dip2B-deficient mouse embryonic lung fibroblast reveals its important roles in cell proliferation and development.

ABSTRACT: Disco-interacting protein 2 homolog B (Dip2B) is a member of Dip2 family encoded by Dip2b gene. Dip2B has been reported to regulate murine epithelial KIT⁺ progenitor cell expansion and differentiation epigenetically via exosomal miRNA targeting during salivary gland organogenesis. However, its molecular functions, cellular activities and biological process remain unstudied. Here, we investigated the transcriptome of Dip2B-deficient mouse embryonic lung fibroblasts (MELFs) isolated from E14.5 embryos by RNA-Seq. Expression profiling identified 1369 and 1104 differentially expressed genes (DEGs) from Dip2b^-/- and Dip2b^+/- MELFs in comparisons to wild-type (Dip2b^+/+ ). Functional clustering of DEGs revealed that many gene

SUBMITTER: Adlat S 

PROVIDER: S-EPMC7502710 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature