Stochastic reaction networks in dynamic compartment populations.

ABSTRACT: Compartmentalization of biochemical processes underlies all biological systems, from the organelle to the tissue scale. Theoretical models to study the interplay between noisy reaction dynamics and compartmentalization are sparse, and typically very challenging to analyze computationally. Recent studies have made progress toward addressing this problem in the context of specific biological systems, but a general and sufficiently effective approach remains lacking. In this work, we propose a mathematical framework based on counting processes that allows us to study dynamic compartment populations with arbitrary interactions and internal biochemistry. We derive an efficient description of the dynamics in terms of differential equations which capture the statistics of the population. We demon

SUBMITTER: Duso L 

PROVIDER: S-EPMC7502757 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature