Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies.

ABSTRACT: Antibodies may bind to bacterial pathogens or their toxins to control infections, and their effector activity is mediated through the recruitment of complement component C1q or the engagement with Fcγ receptors (FcγRs). For bacterial pathogens that rely on a single toxin to cause disease, immunity correlates with toxin neutralization. Most other bacterial pathogens, including Staphylococcus aureus, secrete numerous toxins and evolved multiple mechanisms to escape opsonization and complement killing. Several vaccine candidates targeting defined surface antigens of S. aureus have failed to meet clinical endpoints. It is unclear that such failures can be solely attributed to the poor selection of antibody targets. Thus far, studies to delineate antibody-mediated uptake and killi

SUBMITTER: Chen X 

PROVIDER: S-EPMC7502815 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature