Finding specificity in structural brain alterations through Bayesian reverse inference.

ABSTRACT: In the field of neuroimaging reverse inferences can lead us to suppose the involvement of cognitive processes from certain patterns of brain activity. However, the same reasoning holds if we substitute "brain activity" with "brain alteration" and "cognitive process" with "brain disorder." The fact that different brain disorders exhibit a high degree of overlap in their patterns of structural alterations makes forward inference-based analyses less suitable for identifying brain areas whose alteration is specific to a certain pathology. In the forward inference-based analyses, in fact, it is impossible to distinguish between areas that are altered by the majority of brain disorders and areas that are specifically affected by certain diseases. To address this issue and allow the identificatio

SUBMITTER: Cauda F 

PROVIDER: S-EPMC7502845 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature