Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.

ABSTRACT:

Objective

Several recent studies have shown that the aldosterone synthase gene (CYP11B2) -344C/T polymorphism is related to cardiovascular diseases. However, whether the -344C allele influences the incidence of cardiovascular diseases in Chinese patients with hypertension is unclear.

Methods

Chinese patients with essential hypertension were genotyped for the -344C/T polymorphism in CYP11B2 (n = 755; CC, n = 112; CT, n = 361; TT, n = 282) and followed for 11 years for major adverse cardiovascular events (MACEs), including stroke, onset of coronary artery disease (CAD), and CAD-related death. Established cardiovascular risk factors were used to adjust the multivariate Cox analysis.

Results

After a mean follow-up period of 7.60 ± 1.12 years, a significantly

SUBMITTER: Wang L 

PROVIDER: S-EPMC7503017 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature