Epiregulin promotes hair growth via EGFR-medicated epidermal and ErbB4-mediated dermal stimulation.

ABSTRACT:

Objectives

EREG (epiregulin), a member of the epidermal growth factor (EGF) family, plays a role in inflammation, wound healing, normal physiology and malignancies. However, little is known about its function on hair growth.

Materials and methods

Cell growth assay, QPCR and immunostaining were carried out. Telogen-to-anagen transition and organ culture were conducted. ROS level was monitored by staining DCFDA.

Results

We investigated the hair inductive effect of EREG and the mechanism of stimulation on DPCs and ORS cells during hair cycling. Whereas EREG promoted hair growth, EREG knockdown inhibited hair growth as evidenced by telogen-to-anagen transition and organ culture models. EREG was expressed in epidermal cells including ORS cells in vivo. EREG activated phosp

SUBMITTER: Choi N 

PROVIDER: S-EPMC7503099 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature