Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease.

ABSTRACT: Asymptomatic and symptomatic Alzheimer's disease (AD) subjects may present with equivalent neuropathological burdens but have significantly different antemortem cognitive decline rates. Using the transcriptome as a proxy for functional state, we selected 414 expression profiles of symptomatic AD subjects and age-matched non-demented controls from a community-based neuropathological study. By combining brain tissue-specific protein interactomes with gene networks, we identified functionally distinct composite clusters of genes that reveal extensive changes in expression levels in AD. Global expression for clusters broadly corresponding to synaptic transmission, metabolism, cell cycle, survival, and immune response were downregulated, while the upregulated cluster included largely uncharacte

SUBMITTER: Canchi S 

PROVIDER: S-EPMC7503200 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature