Partial absence of PD-1 expression by tumor-infiltrating EBV-specific CD8⁺ T cells in EBV-driven lymphoepithelioma-like carcinoma.

ABSTRACT:

Objectives

Lymphoepithelioma-like carcinoma (LELC) is an uncommon lung cancer, typically observed in young, non-smoking Asian populations. LELC is associated with Epstein-Barr virus (EBV) infection of lung tumor cells of epithelial origin, suggesting a carcinogenic role of EBV as observed in nasopharyngeal carcinoma (NPC). Here, we studied the antigen specificity and phenotype of EBV-specific CD8⁺ T cells in blood and tumor of one LELC patient positive for EBV infection in lung tumor cells.

Methods

Using multiplex MHC class I tetramers, mass cytometry and mRNA sequencing, we studied EBV-specific CD8⁺ T cells at the transcriptomic and phenotypic levels in blood and tumor tissues of the LELC patient.

Results

Lymphoepithelioma-like carcinoma lung tu

SUBMITTER: Simoni Y 

PROVIDER: S-EPMC7503213 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature