A Translational Paradigm to Study the Effects of Uncontrollable Stress in Humans.

ABSTRACT: Theories on the aetiology of depression in humans are intimately linked to animal research on stressor controllability effects. However, explicit translations of established animal designs are lacking. In two consecutive studies, we developed a translational paradigm to study stressor controllability effects in humans. In the first study, we compared three groups of participants, one exposed to escapable stress, one yoked inescapable stress group, and a control group not exposed to stress. Although group differences indicated successful stress induction, the manipulation failed to differentiate groups according to controllability. In the second study, we employed an improved paradigm and contrasted only an escapable stress group to a yoked inescapable stress group. The final design success

SUBMITTER: Meine LE 

PROVIDER: S-EPMC7503322 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature