Structural and Functional Maturation of Rat Primary Motor Cortex Layer V Neurons.

ABSTRACT: Rodent neocortical neurons undergo prominent postnatal development and maturation. The process is associated with structural and functional maturation of the axon initial segment (AIS), the site of action potential initiation. In this regard, cell size and optimal AIS length are interconnected. In sensory cortices, developmental onset of sensory input and consequent changes in network activity cause phasic AIS plasticity that can also control functional output. In non-sensory cortices, network input driving phasic events should be less prominent. We, therefore, explored the relationship between postnatal functional maturation and AIS maturation in principal neurons of the primary motor cortex layer V (M1LV), a non-sensory area of the rat brain. We hypothesized that a rather continuous proc

SUBMITTER: Benedetti B 

PROVIDER: S-EPMC7503395 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature