Decoding Susceptibility to Respiratory Viral Infections and Asthma Inception in Children.

ABSTRACT: Human Respiratory Syncytial Virus and Human Rhinovirus are the most frequent cause of respiratory tract infections in infants and children and are major triggers of acute viral bronchiolitis, wheezing and asthma exacerbations. Here, we will discuss the application of the powerful tools of systems biology to decode the molecular mechanisms that determine risk for infection and subsequent asthma. An important conceptual advance is the understanding that the innate immune system is governed by a Bow-tie architecture, where diverse input signals converge onto a few core pathways (e.g., IRF7), which in turn generate diverse outputs that orchestrate effector and regulatory functions. Molecular profiling studies in children with severe exacerbations of asthma/wheeze have identified two major immu

SUBMITTER: Read JF 

PROVIDER: S-EPMC7503410 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature