Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei.

ABSTRACT: The modern world has no available drugs for the treatment of enteroviruses (EV), which affect millions of people worldwide each year. The EV71 is a major causative disease for hand, foot, and mouth disease; sometimes it is associated with severe central nervous system diseases. Treatment for enteroviral infection is mainly supportive; treatment for aseptic meningitis caused by enteroviruses is also generally symptomatic. Upon the urgent request of new anti-enterovirus drugs, a series of hinged aromatic compounds with polynulei were synthesized through two different chemical pathways. Among these morpholine-furan/thiophene/pyrrole-benzene-pyrazole conjugates, three new agents exhibited inhibitory activity with EC50 = 2.29-6.16 μM toward EV71 strain BrCr in RD cells. Their selectivity index

SUBMITTER: Hwu JR 

PROVIDER: S-EPMC7503712 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature