Targeting the Mitochondrial Metabolic Network: A Promising Strategy in Cancer Treatment.

ABSTRACT: Metabolic reprogramming is a hallmark of cancer, which implements a profound metabolic rewiring in order to support a high proliferation rate and to ensure cell survival in its complex microenvironment. Although initial studies considered glycolysis as a crucial metabolic pathway in tumor metabolism reprogramming (i.e., the Warburg effect), recently, the critical role of mitochondria in oncogenesis, tumor progression, and neoplastic dissemination has emerged. In this report, we examined the main mitochondrial metabolic pathways that are altered in cancer, which play key roles in the different stages of tumor progression. Furthermore, we reviewed the function of important molecules inhibiting the main mitochondrial metabolic processes, which have been proven to be promising anticancer candi

SUBMITTER: Frattaruolo L 

PROVIDER: S-EPMC7503725 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature