Air Pollution and Atopic Dermatitis (AD): The Impact of Particulate Matter (PM₁₀) on an AD Mouse-Model.

ABSTRACT: Air pollution reportedly contributes to the development and exacerbation of atopic dermatitis (AD). However, the exact mechanism underlying this remains unclear. To examine the relationship between air pollution and AD, a clinical, histological, and genetic analysis was performed on particulate matter (PM)-exposed mice. Five-week-old BALB/c mice were randomly divided into four groups (control group, ovalbumin (OVA) group, PM group, OVA + PM group; n = 6) and treated with OVA or PM_10, alone or together. Cutaneous exposure to OVA and PM₁₀ alone resulted in a significant increase in skin severity scores, trans-epidermal water loss (TEWL) and epidermal thickness compared to the control group at Week 6. The findings were further accentuated in the OVA + PM group sho

SUBMITTER: Woo YR 

PROVIDER: S-EPMC7503766 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature