Genome-wide chromosomal instability by cell-free DNA sequencing predicts survival in patients with metastatic breast cancer.

ABSTRACT:

Background

Genome-wide chromosomal instability, instead of specific somatic mutations or copy-number alterations in selected genes, is a significant property of cancer and may suggest a new strategy for treatment. Here we utilized cell-free DNA (cfDNA) sequencing to display the whole picture of chromosomal instability in patients with metastatic breast cancer (MBC), and evaluate its predictive value for patient survival.

Methods

The clinical data of 65 patients who had frozen plasma and planned to change the therapeutic regimen were retrospectively enrolled. Low-coverage whole-genome sequencing of cfDNA was performed to generate the chromosomal instability represented by chromosomal instability (CIN) score.

Results

Tumors with diverse status of hormone receptor and HE

SUBMITTER: Mo H 

PROVIDER: S-EPMC7503795 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature