Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naive Non-Affective First Episode Psychosis Individuals: A 3-Month Study.

ABSTRACT: Toll-like receptors (TLRs) are a pivotal component of the innate immune system that seem to have a role in the pathogenesis of psychosis. The purpose of this work was to compare the expression and functionality of 9 TLRs in three peripheral blood mononuclear cells (PBMCs) (monocytes, B cells, and T cells) between 33 drug-naïve first-episode psychosis (FEP) individuals and 26 healthy volunteers, at baseline and after 3-month of antipsychotic treatment. The expression of TLRs 1-9 were assessed by flow cytometry. For the assessment of the TLR functionality, cells collected in sodium heparin tubes were polyclonally stimulated for 18 h, with different agonists for human TLR1-9. The results of our study highlight the role that TLR5 and TLR8 might play in the pathophysiology of psychosis. We foun

SUBMITTER: Juncal-Ruiz M 

PROVIDER: S-EPMC7504008 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature