Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C.

ABSTRACT: Various pathological processes in humans are associated with biogenic iron accumulation and the mineralization of iron oxide nanoparticles, especially magnetite. Ferritin has been proposed as a precursor to pathological magnetite mineralization. This study quantifies spectroscopically the release of ferrous ions from native ferritin and magnetoferritin as a model system for pathological ferritin in the presence of potent natural reducing agents (vitamins C and B2) over time. Ferrous cations are required for the transformation of ferrihydrite (physiological) into a magnetite (pathological) mineral core and are considered toxic at elevated levels. The study shows a significant difference in the reduction and iron release from native ferritin compared to magnetoferritin for both vitamins. The

SUBMITTER: Strbak O 

PROVIDER: S-EPMC7504058 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature