Redox Signaling and Regional Heterogeneity of Endothelial Dysfunction in db/db Mice.

ABSTRACT: The variable nature of vascular dysfunction in diabetes is not well understood. We explored the functional adaptation of different arteries in db/db mice in relation to increased severity and duration of diabetes. We compared endothelium-dependent and -independent vasodilation in the aortae, as well as the carotid and femoral arteries, of db/db mice at three ages in parallel with increased body weight, oxidative stress, and deterioration of glycemic control. Vascular responses to in vitro generation of reactive oxygen species (ROS) and expression of superoxide dismutase (SOD) isoforms were assessed. There was a progressive impairment of endothelium-dependent and -independent vasorelaxation in the aortae of db/db mice. The carotid artery was resistant to the effects of in vivo and in vitro

SUBMITTER: Sallam NA 

PROVIDER: S-EPMC7504187 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature