Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

ABSTRACT:

Background

It is unclear whether immune escape-associated mutations in the major hydrophilic region of hepatitis B virus surface antigen (HBsAg) are associated with nucleoside/nucleotide analog resistance.

Aim

To evaluate the association between immune escape-associated mutations and nucleoside/nucleotide analog resistance mutations.

Methods

In total, 19440 patients with chronic hepatitis B virus infection, who underwent resistance testing at the Fifth Medical Center of Chinese PLA General Hospital between July 2007 and December 2017, were enrolled. As determined by sequence analysis, 6982 patients harbored a virus with resistance mutations and 12458 harbored a virus lacking resistance mutations. Phenotypic analyses were performed to evaluate HBsAg production, replica

SUBMITTER: Huang BX 

PROVIDER: S-EPMC7504243 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature