Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers.

ABSTRACT: Mitochondrial carriers are a family of structurally related proteins responsible for the exchange of metabolites, cofactors and nucleotides between the cytoplasm and mitochondrial matrix. The in silico analysis of the Drosophila melanogaster genome has highlighted the presence of 48 genes encoding putative mitochondrial carriers, but only 20 have been functionally characterized. Despite most Drosophila mitochondrial carrier genes having human homologs and sharing with them 50% or higher sequence identity, D. melanogaster genes display peculiar differences from their human counterparts: (1) in the fruit fly, many genes encode more transcript isoforms or are duplicated, resulting in the presence of numerous subfamilies in the genome; (2) the expression of the energy-producing g

SUBMITTER: Curcio R 

PROVIDER: S-EPMC7504413 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature