Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease.

ABSTRACT:

Background

There is an urgent need to understand the pathways and processes underlying Alzheimer's disease (AD) for early diagnosis and development of effective treatments. This study was aimed to investigate Alzheimer's dementia using an unsupervised lipid, protein and gene multi-omics integrative approach.

Methods

A lipidomics dataset comprising 185 AD patients, 40 mild cognitive impairment (MCI) individuals and 185 controls, and two proteomics datasets (295 AD, 159 MCI and 197 controls) were used for weighted gene co-expression network analyses (WGCNA). Correlations of modules created within each modality with clinical AD diagnosis, brain atrophy measures and disease progression, as well as their correlations with each other, were analyzed. Gene ontology enrichment analys

SUBMITTER: Xu J 

PROVIDER: S-EPMC7504646 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature