Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status.

ABSTRACT:

Background

Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut microbiota and the potential role of the microbiome in influencing sex steroid hormones and shaping sexually dimorphic susceptibility to disease have been largely overlooked. Although there is some evidence of sex-specific differences in the gut microbiota diversity, composition, and functionality, the results are inconsistent. Importantly, most of these studies have not taken into account the gonadal steroid status. Therefore, we investigated the gut microbiome composition and functionalit

SUBMITTER: Mayneris-Perxachs J 

PROVIDER: S-EPMC7504665 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature