Melatonin deficiency decreases brown adipose tissue acute thermogenic capacity of in rats measured by ¹⁸F-FDG PET.

ABSTRACT:

Objective

Melatonin has been shown to increase brown adipose tissue (BAT) mass, which can lead to important metabolic effects, such as bodyweight reduction and glycemic improvement. However, BAT mass can only be measured invasively and. The gold standard for non-invasive measurement of BAT activity is positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-d-glucose (¹⁸F-FDG PET). There is no study, to our knowledge, that has evaluated if melatonin influences BAT activity, measured by this imaging technique in animals.

Methods

Three experimental groups of Wistar rats (control, pinealectomy, and pinealectomy replaced with melatonin) had an ¹⁸F-FDG PET performed at room temperature and after acute cold exposure. The ratio of increased BAT activit

SUBMITTER: Halpern B 

PROVIDER: S-EPMC7504678 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature