Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis.

ABSTRACT:

Background

In human immunodeficiency virus-1 (HIV-1) infection, activation of astrocytes induces imbalance in physiological functions due to perturbed astrocytic functions that unleashes toxicity on neurons. This leads to inflammatory response finally culminating into neurocognitive dysfunction. In neuroAIDS, HIV-1 protein, transactivator of transcription (Tat) is detected in the cerebrospinal fluid of infected patients. Mortalin, a multifunctional protein, has anti-inflammatory role following its activation in various stress conditions. Recent studies demonstrate downregulation of mortalin in neurodegenerative diseases. Here, we explored the mechanisms of mortalin in modulating HIV-1 Tat-mediated neuroinflammation.

Methods

Expression of mortalin in autopsy section in normal

SUBMITTER: Priyanka 

PROVIDER: S-EPMC7504834 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature