Expression correlation attenuates within and between key signaling pathways in chronic kidney disease.

ABSTRACT:

Background

Compared to the conventional differential expression approach, differential coexpression analysis represents a different yet complementary perspective into diseased transcriptomes. In particular, global loss of transcriptome correlation was previously observed in aging mice, and a most recent study found genetic and environmental perturbations on human subjects tended to cause universal attenuation of transcriptome coherence. While methodological progresses surrounding differential coexpression have helped with research on several human diseases, there has not been an investigation of coexpression disruptions in chronic kidney disease (CKD) yet.

Methods

RNA-seq was performed on total RNAs of kidney tissue samples from 140 CKD patients. A combination of differentia

SUBMITTER: Yu H 

PROVIDER: S-EPMC7504859 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature