Acute in vivo pulmonary toxicity assessment of occupationally relevant particulate matter from a cellulose nanofiber board.

ABSTRACT: Cellulose nanofibers (CNFs) are an emerging engineered nanomaterial that are utilized in a variety of applications, including as a replacement for urea-formaldehyde, and other adhesives, as the binding agent in manufactured fiber and particle boards. To ensure the health and well-being of those producing, installing, or otherwise using cellulose nanofiber boards (CNFBs) it is imperative that the particulate matter (PM) produced during CNFB manipulation be evaluated for toxicity. We developed and internally verified a generation system to examine the PM produced by sanding CNFB using aluminum oxide sandpaper. With 80-grit sandpaper our system produced a low dispersity aerosol, as determined by a scanning mobility particle sizer and an optical particle counter, with a geometric mean of 28 nm

SUBMITTER: Parizek NJ 

PROVIDER: S-EPMC7504912 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature