A new model for <i>Trypanosoma cruzi</i> heme homeostasis depends on modulation of <i>Tc</i>HTE protein expression.

ABSTRACT: Heme is an essential cofactor for many biological processes in aerobic organisms, which can synthesize it de novo through a conserved pathway. Trypanosoma cruzi, the etiological agent of Chagas disease, as well as other trypanosomatids relevant to human health, are heme auxotrophs, meaning they must import it from their mammalian hosts or insect vectors. However, how these species import and regulate heme levels is not fully defined yet. It is known that the membrane protein TcHTE is involved in T. cruzi heme transport, although its specific role remains unclear. In the present work, we studied endogenous TcHTE in the different life cycle stages of the parasite to gain insight into its function in heme transport and homeostasis. We have confirmed that

SUBMITTER: Pagura L 

PROVIDER: S-EPMC7504937 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature