Suppression of Chlamydial Pathogenicity by Nonspecific CD8⁺ T Lymphocytes.

ABSTRACT: Chlamydia trachomatis, a leading infectious cause of tubal infertility, induces upper genital tract pathology, such as hydrosalpinx, which can be modeled with Chlamydia muridarum infection in mice. Following C. muridarum inoculation, wild-type mice develop robust hydrosalpinx, but OT1 mice fail to do so because their T cell receptors are engineered to recognize a single ovalbumin epitope (OVA_457-462). These observations have demonstrated a critical role of Chlamydia-specific T cells in chlamydial pathogenicity. In the current study, we have also found that OT1 mice can actively inhibit chlamydial pathogenicity. First, depletion of CD8⁺ T cells from OT1 mice led to the induction of significant hydrosalpinx by Chlamydia, indicating tha

SUBMITTER: Xie L 

PROVIDER: S-EPMC7504968 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature