Common Bacterial Infections and Risk of Dementia or Cognitive Decline: A Systematic Review.

ABSTRACT:

Background

Bacterial infections may be associated with dementia, but the temporality of any relationship remains unclear.

Objectives

To summarize existing literature on the association between common bacterial infections and the risk of dementia and cognitive decline in longitudinal studies.

Methods

We performed a comprehensive search of 10 databases of published and grey literature from inception to 18 March 2019 using search terms for common bacterial infections, dementia, cognitive decline, and longitudinal study designs. Two reviewers independently performed the study selection, data extraction, risk of bias and overall quality assessment. Data were summarized through a narrative synthesis as high heterogeneity precluded a meta-analysis.

Results

We identifi

SUBMITTER: Muzambi R 

PROVIDER: S-EPMC7504996 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature