Dynamical modeling of pro- and anti-inflammatory cytokines in the early stage of septic shock.

ABSTRACT: A dynamical model of the pathophysiological behaviors of IL18 and IL10 cytokines with their receptors is tested against data for the case of early sepsis. The proposed approach considers the surroundings (organs and bone marrow) and the different subsystems (cells and cyctokines). The interactions between blood cells, cytokines and the surroundings are described via mass balances. Cytokines are adsorbed onto associated receptors at the cell surface. The adsorption is described by the Langmuir model and gives rise to the production of more cytokines and associated receptors inside the cell. The quantities of pro and anti-inflammatory cytokines present in the body are combined to give global information via an inflammation level function which describes the patient's state. Data for paramete

SUBMITTER: Tallon J 

PROVIDER: S-EPMC7505012 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature