Genetic variation and selection in the major histocompatibility complex Class II gene in the Guizhou pony.

ABSTRACT: The Guizhou pony (GZP) is an indigenous species of equid found in the mountains of the Guizhou province in southwest China. We selected four regions of the equine leukocyte antigen (ELA), including DQA, DRA, DQB, and DRB, and used them to assess the diversity of the major histocompatibility complex (MHC) class II gene using direct sequencing technology. DRA had the lowest d _N/d _S ratio (0.560) compared with the other three loci, indicating that DRA was conserved and could be conserved after undergoing selective processes. Nine DQA, five DQB, nine DRA, and seven DRB codons were under significant positive selection at the antigen binding sites (ABS), suggesting that the selected residues

SUBMITTER: Liu C 

PROVIDER: S-EPMC7505079 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature