The Information Content of Glutamine-Rich Sequences Define Protein Functional Characteristics.

ABSTRACT: The presence of abnormally expanded glutamine (Q) repeats within specific proteins (e.g., huntingtin) are the well-established cause of several neurogenerative diseases, including Huntington disease and spinocerebellar ataxias. However, the impact of "expanded Q" stretches on the protein function is not well-understood, mostly due to lack of knowledge about the physiological role of Q repeats and the mechanism by which these repeats achieve functional-specificity. Indeed, is intriguing that regions with such low complexity (low information content) can display exquisite functional specificity. Prompting the question: where is this information stored? Applying biochemical/structural constraints and statistical analysis of protein composition we identified Q-rich (Q_R) regio

SUBMITTER: Sen A 

PROVIDER: S-EPMC7505158 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature