Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity.

ABSTRACT: Although the relationship between schizophrenia spectrum disorder (SSD) and autism spectrum disorder (ASD) has long been debated, it has not yet been fully elucidated. The authors quantified and visualized the relationship between ASD and SSD using dual classifiers that discriminate patients from healthy controls (HCs) based on resting-state functional connectivity magnetic resonance imaging. To develop a reliable SSD classifier, sophisticated machine-learning algorithms that automatically selected SSD-specific functional connections were applied to Japanese datasets from Kyoto University Hospital (N = 170) including patients with chronic-stage SSD. The generalizability of the SSD classifier was tested by 2 independent validation cohorts, and 1 cohort including first-episode schizophrenia.

SUBMITTER: Yoshihara Y 

PROVIDER: S-EPMC7505174 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature