Immunogenicity of influenza vaccines administered to pregnant women in randomized clinical trials in Mali and South Africa.

ABSTRACT:

Background

A key consideration for expanding recommendations for influenza vaccination is a robust assessment of immunogenicity and efficiency of transplacental antibody transfer after maternal vaccination.

Methods

We pooled data from two trials of maternal influenza vaccination to analyze vaccine immunogenicity with more power than either trial had alone. We compared hemagglutination-inhibition (HAI) titers and titer factor change for women and their infants between trial arms using t-tests; maternal and infant putative seroprotective titers (HAI ≥ 1:40) within each trial arm and maternal seroconversion between trial arms using exact tests; and transplacental antibody transfer between trial arms using t-tests. We used marginal linear models and generalized estimating equati

SUBMITTER: Amin AB 

PROVIDER: S-EPMC7505225 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature