Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC7505278 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Aging and disease 20201001 5
The switch between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a key role in aging-induced osteoporosis. In this study, miR-19a-3p was obviously downregulated in BMSCs from aged humans and mice. Overexpressed miR-19a-3p evidently reduced aging-induced bone loss in mice and promoted osteogenic differentiation of BMSCs, while silenced miR-19a-3p manifestly increased aging-induced bone loss in mice and repressed osteogenic differentiation of BMSCs. ...[more]