Facility-dependent metabolic phenotype and gut bacterial composition in CD-1 mice from a single vendor: A brief report.

ABSTRACT: Utilization of murine models remains a valuable tool in biomedical research, yet, disease phenotype of mice across studies can vary considerably. With advances in next generation sequencing, it is increasingly recognized that inconsistencies in host phenotype can be attributed, at least in part, to differences in gut bacterial composition. Research with inbred murine strains demonstrates that housing conditions play a significant role in variations of gut bacterial composition, however, few studies have assessed whether observed variation influences host phenotype in response to an intervention. Our study initially sought to examine the effects of a long-term (9-months) dietary intervention (i.e., diets with distinct fatty acid compositions) on the metabolic health, in particular glucose h

SUBMITTER: Unger AL 

PROVIDER: S-EPMC7505418 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature