STrengthening the Reporting Of Pharmacogenetic Studies: Development of the STROPS guideline.

ABSTRACT:

Background

Large sample sizes are often required to detect statistically significant associations between pharmacogenetic markers and treatment response. Meta-analysis may be performed to synthesize data from several studies, increasing sample size and, consequently, power to detect significant genetic effects. However, performing robust synthesis of data from pharmacogenetic studies is often challenging because of poor reporting of key data in study reports. There is currently no guideline for the reporting of pharmacogenetic studies that has been developed using a widely accepted robust methodology. The objective of this project was to develop the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline.

Methods and findings

We established a preliminary ch

SUBMITTER: Chaplin M 

PROVIDER: S-EPMC7505422 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature