Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier.

ABSTRACT: Exosomes are vesicles involved in intercellular communication. Their membrane structure and core content is largely dependent on the cell of origin. Exosomes have been investigated both for their biological roles and their possible use as disease biomarkers and drug carriers. These potential technological applications require the rigorous characterization of exosomal blood brain barrier permeability and a description of their lipid bilayer composition. To achieve these goals, we have established a 3D static blood brain barrier system based on existing systems for liposomes and a complementary LC-MS/MS and 31P nuclear magnetic resonance methodology for the analysis of purified human plasma-derived exosome-like vesicles. Results show that the isolated vesicles pass the blood brain barrier an

SUBMITTER: Jakubec M 

PROVIDER: S-EPMC7505448 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature