Tumor targeting vitamin B12 derivatives for X-ray induced treatment of pancreatic adenocarcinoma.

ABSTRACT:

Background

X-Ray induced phototherapy is highly sought after as it provides a deep tissue, synergistic method of treating cancers via standard-of-care radiotherapy. When this is combined with releasable chemotherapy agents, it can provide high target selectivity, with reduced off-target organ effects that limit current systemic therapies. We have recently developed a unique light-activated drug delivery system whereby the drug is conjugated to an alkylcobalamin scaffold. Alkylcobalamins are actively transported into cells by transcobalamin receptors (TCblR), which are overexpressed in a variety of cancer types. We hope to utilize this cobalamin scaffold technology for drug delivery in pancreatic adenocarcinoma (PDAC) cancer.

Methods

The ability of the cobalamin scaffold to s

SUBMITTER: Gendron LN 

PROVIDER: S-EPMC7505481 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature