Selective pressure on SARS-CoV-2 protein coding genes and glycosylation site prediction.

ABSTRACT:

Background

An outbreak of a febrile respiratory illness due to the newly discovered Coronavirus, SARS-CoV-2, was initially detected in mid-December 2019 in the city of Wuhan, Hubei province (China). The virus then spread to most countries in the world. As an RNA virus, SARS-CoV-2 may acquire mutations that may be fixed. The aim of this study was to evaluate the selective pressure acting on SARS-CoV-2 protein coding genes.

Methods

Mutations and glycosylation site prediction were analyzed in SARS-CoV-2 genomes (from 464 to 477 sequences).

Results

Selective pressure on surface glycoprotein (S) revealed one positively selected site (AA 943), located outside the receptor binding domain (RBD). Mutation analysis identified five residues on the surface glycoprotein, wi

SUBMITTER: Lo Presti A 

PROVIDER: S-EPMC7505600 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature