Association of familial history of diabetes or myocardial infarction and stroke with risk of cardiovascular diseases in four German cohorts.

ABSTRACT: Since family history of diabetes is a very strong risk factor for type 2 diabetes, which is one of the most important risk factors for cardiovascular disease (CVD), it might be also useful to assess the risk for CVD. Therefore, we aimed to investigate the relationship between a familial (parents and siblings) history of diabetes and the risk of incident CVD. Data from four prospective German cohort studies were used: EPIC-Potsdam study (n = 26,054), CARLA study (n = 1,079), SHIP study (n = 3,974), and KORA study (n = 15,777). A multivariable-adjusted Cox regression was performed to estimate associations between familial histories of diabetes, myocardial infarction or stroke and the risk of CVD in each cohort; combined hazard ratios (HR_Meta) were derived by conducting a meta-anal

SUBMITTER: Muhlenbruch K 

PROVIDER: S-EPMC7505832 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature