Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model.

ABSTRACT: Background: We previously demonstrated that celastrol has significant anti-inflammatory and bone protective effects when administered via the intraperitoneal route. For further preclinical evaluation, an effective oral administration of celastrol is crucial. Here we aimed to study the therapeutic dose range for its oral administration. Methods: Celastrol (1-25 μg/g/day, N = 5/group) was administrated orally to female adjuvant-induced arthritis (AIA) rats after 8 days of disease induction for a period of 14 days. A group of healthy (N = 8) and arthritic (N = 15) gender- and age-matched Wistar rats was used as controls. During the treatment period, the inflammatory score, ankle perimeter, and body weight were measured. At the end of the treatment, the anima

SUBMITTER: Cascao R 

PROVIDER: S-EPMC7505947 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature