Ruthenium (II) complex cis-[Ru^II(ŋ²-O₂CC₇H₇O₂)(dppm)₂]PF₆-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity.

ABSTRACT: Ruthenium complexes have been extensively explored as potential molecules for cancer treatment. Considering our previous findings on the remarkable cytotoxic activity exhibited by the ruthenium (II) complex 3-hydroxy-4-methoxybenzoate (hmxbato)-cis-[Ru^II(ŋ²-O₂CC₇H₇O₂)(dppm)₂]PF₆ against Leishmania promastigotes and also the similar metabolic characteristics between trypanosomatids and tumor cells, the present study aimed to analyze the anticancer potential of hmxbato against lung tumor cells, as well as the partial death mechanisms involved. Hmxbato demonstrated selective cytotoxicity against A549 lung tumor cells. In addition, this complex at a concentration of 3.8 µM was able to expressively increase

SUBMITTER: Costa MS 

PROVIDER: S-EPMC7506019 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature