Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils.

ABSTRACT: The importance of the intracellular Ca²⁺ concentration ([Ca²⁺]_i) in neutrophil function has been intensely studied. However, the role of the intracellular Na⁺ concentration ([Na⁺]_i) which is closely linked to the intracellular Ca²⁺ regulation has been largely overlooked. The [Na⁺]_i is regulated by Na⁺ transport proteins such as the Na⁺/Ca²⁺-exchanger (NCX1), Na⁺/K⁺-ATPase, and Na⁺-permeable, transient receptor potential melastatin 2 (TRPM2) channel. Stimulating with either N-formylmethionine-leucyl-phenylalanine (fMLF) or complement protein C5a causes distinct changes of the [Na⁺]_i. fMLF induces a sustaine

SUBMITTER: Najder K 

PROVIDER: S-EPMC7506047 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature