Glucocorticoid treatment is associated with ICU-acquired hypernatremia: a nested case-control study.

ABSTRACT:

Background

Hypernatremia is a major electrolyte disorder associated with death among critically ill patients. Glucocorticoid therapy may cause hypernatremia in refractory septic shock patients, but the association between glucocorticoid and intensive care unit (ICU)-acquired hypernatremia (IAH) remains unclear. The aim of this study was to clarify whether glucocorticoid administration was associated with IAH.

Methods

This was a nested case-control study using data from an established cohort including 121 IAH cases identified from 1756 patients who were admitted to ICU in a tertiary care facility in Japan. We included patients who were admitted with a normal range of serum sodium concentrations (130-149 mEq/L) from January 1, 2013 to December 31, 2015 and remained in ICU for 

SUBMITTER: Imaizumi T 

PROVIDER: S-EPMC7506169 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature