Mortality after Transplantation for Hepatocellular Carcinoma: A Study from the European Liver Transplant Registry.

ABSTRACT:

Background and aims

Prognosis after liver transplantation differs between hepatocellular carcinoma (HCC) arising in cirrhotic and non-cirrhotic livers and aetiology is poorly understood. The aim was to investigate differences in mortality after liver transplantation between these patients.

Methods

We included patients from the European Liver Transplant Registry transplanted due to HCC from 1990 to November 2016 and compared cirrhotic and non-cirrhotic patients using propensity score (PS) calibration of Cox regression estimates to adjust for unmeasured confounding.

Results

We included 22,787 patients, of whom 96.5% had cirrhosis. In the unadjusted analysis, non-cirrhotic patients had an increased risk of overall mortality with a hazard ratio (HR) of 1.37 (95% confidenc

SUBMITTER: Pommergaard HC 

PROVIDER: S-EPMC7506266 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature