Association of Early-Life Adversity With Measures of Accelerated Biological Aging Among Children in China.

ABSTRACT:

Importance

A growing body of literature suggests that exposure to early-life adversity (ELA) is associated with accelerated biological aging, offering 1 mechanism through which ELA may be associated with an increased risk for age-related disease. These investigations, however, have been predominantly cross-sectional and focused on adults and females.

Objective

To evaluate associations of threat-related (ie, physical abuse) and deprivation-related (ie, emotional neglect) ELA exposure with cellular and reproductive strategy metrics of biological aging among boys and girls with specific genetic backgrounds around the period of pubertal onset.

Design, setting, and participants

In this cohort study, 997 boys and girls in grade 1 to grade 3 from 3 large elementary schools w

SUBMITTER: Sun Y 

PROVIDER: S-EPMC7506517 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature